StressCovidV1, 2020, Analysis, bibRecord, 000307

Oseltamivir and S-Adenosyl-L-Methionine Combination as Effective Therapeutic Strategy for Suppression of Oxidative Damage in Lung Caused by Influenza Virus Infection in Mice.

Identifieur interne : 000307 ( 2020/Analysis ); précédent : 000306; suivant : 000308

Oseltamivir and S-Adenosyl-L-Methionine Combination as Effective Therapeutic Strategy for Suppression of Oxidative Damage in Lung Caused by Influenza Virus Infection in Mice.

Auteurs : Milka Mileva [Bulgarie] ; Adriana Dimitrova [Bulgarie] ; Dimo Krastev [Bulgarie] ; Albena Alexandrova [Bulgarie] ; Elina Tsvetanova [Bulgarie] ; Almira Georgieva [Bulgarie] ; Angel Galabov [Bulgarie]

Source :

Drug research [ 2194-9387 ] ; 2020.

RBID : pubmed:32316058

Abstract

The pathogenesis of influenza infection is associated with two general processes in the body: (a) lung damage based on virus replication; (b) overproduction of free radicals, antioxidant deficiency, and development of oxidative stress. To attack these aspects of flu pathogenesis, we explored the combined effect of the antiviral agent oseltamivir, and s-adenosyl-l-methionine (SAM) as a precursor of the endogenous antioxidant glutathione, in mice infected with influenza virus.

DOI: 10.1055/a-1147-8824
PubMed: 32316058

Affiliations:

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pubmed:32316058

Le document en format XML

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Oseltamivir and S-Adenosyl-L-Methionine Combination as Effective Therapeutic Strategy for Suppression of Oxidative Damage in Lung Caused by Influenza Virus Infection in Mice.

Oseltamivir and S-Adenosyl-L-Methionine Combination as Effective Therapeutic Strategy for Suppression of Oxidative Damage in Lung Caused by Influenza Virus Infection in Mice.

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Abstract

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